abstract：:Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions....

journal_title：Neurotoxicology and teratology

authors： Lasley SM,Gilbert ME

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Epidemiological studies examining the effects of prenatal toxic heavy metals exposure on neonatal development at the population-based level are limited. OBJECTIVE:To explore prenatal exposure levels to toxic heavy metals and examine whether exposure is associated with neonatal development. METHODS:A strati...

journal_title：Neurotoxicology and teratology

authors： Yu XD,Yan CH,Shen XM,Tian Y,Cao LL,Yu XG,Zhao L,Liu JX

更新日期：2011-07-01 00:00:00

abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

journal_title：Neurotoxicology and teratology

authors： Dribben WH,Creeley CE,Farber N

更新日期：2011-07-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：:In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO₃) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V₁ group) or with 7.2 mg/kg bw/day of NaVO₃ (V₂ group) for 5 consecutive days. Results show tha...

journal_title：Neurotoxicology and teratology

authors： Cuesta S,Francés D,García GB

更新日期：2011-03-01 00:00:00

abstract：:Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...

journal_title：Neurotoxicology and teratology

authors： Powers CM,Levin ED,Seidler FJ,Slotkin TA

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported a significant association between early childhood Pb levels and cardiovascular response to acute stress. The current study considers the association betw...

journal_title：Neurotoxicology and teratology

authors： Gump BB,Mackenzie JA,Bendinskas K,Morgan R,Dumas AK,Palmer CD,Parsons PJ

更新日期：2011-03-01 00:00:00

abstract：:Ethanol exposure on gestational day (GD) 7 in the mouse has previously been shown to result in ventromedian forebrain deficits along with facial anomalies characteristic of fetal alcohol syndrome (FAS). To further explore ethanol's teratogenic effect on the ventromedian forebrain in this mouse model, scanning electron...

journal_title：Neurotoxicology and teratology

authors： Godin EA,Dehart DB,Parnell SE,O'Leary-Moore SK,Sulik KK

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Prenatal tobacco exposure is a risk factor for the development of externalizing behaviors and is associated with several adverse health outcomes. Because pregnancy smoking is a complex behavior with both daily fluctuations and changes over the course of pregnancy, quantifying tobacco exposure is a significan...

journal_title：Neurotoxicology and teratology

authors： Fang H,Johnson C,Stopp C,Espy KA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...

journal_title：Neurotoxicology and teratology

authors： Shoemaker RC,House D,Ryan JC

更新日期：2010-11-01 00:00:00

abstract：:Following the passage of the Food Quality Protection Act, which mandated an increased focus on evaluating the potential toxicity of pesticides to children, the number of guideline developmental neurotoxicity (DNT) studies (OPPTS 870.6300) submitted to the U.S. Environmental Protection Agency (EPA) Office of Pesticide ...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Rowland J,May B,Makris SL,Schumacher K,Scarano LJ

更新日期：2010-09-01 00:00:00

abstract：:Seizures have been reported to modify neural development in the immature brain. In this study, we attempted to determine whether pentylenetetrazol (a GABAergic receptor antagonist, PTZ)-induced seizures influence cell proliferation in zebrafish larvae (5 and 15 days of post-fertilization), using bromodeoxyuridine (Brd...

journal_title：Neurotoxicology and teratology

authors： Kim YH,Lee Y,Lee K,Lee T,Kim YJ,Lee CJ

更新日期：2010-09-01 00:00:00

abstract：:Research suggests that use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. We examined the effects of 2mg/kg (9)-tetrahydrocannabinol (THC) administered daily via intra-peritoneal injections during juvenile/early adolescence...

journal_title：Neurotoxicology and teratology

authors： Harte LC,Dow-Edwards D

更新日期：2010-09-01 00:00:00

abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

journal_title：Neurotoxicology and teratology

authors： Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments. OBJECTIVE:We tested whether comparable effects occur in C57BL/6 mice. METHOD:C57BL/6 mice were treated with 10mg/kgs.c.x4 MA on a single d...

journal_title：Neurotoxicology and teratology

authors： Grace CE,Schaefer TL,Herring NR,Graham DL,Skelton MR,Gudelsky GA,Williams MT,Vorhees CV

更新日期：2010-05-01 00:00:00

abstract：:Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific per...

journal_title：Neurotoxicology and teratology

authors： Braquenier JB,Quertemont E,Tirelli E,Plumier JC

更新日期：2010-03-01 00:00:00

abstract：:The indirubins long have been used in Chinese medicine for treatment of myelocytic leukemia. Among the many more recently described biological activities of the indirubins, attention has been directed toward the ability of these compounds to inhibit GSK-3 and CDKs, kinases implicated in neurodegenerative conditions. L...

journal_title：Neurotoxicology and teratology

authors： Magiatis P,Polychronopoulos P,Skaltsounis AL,Lozach O,Meijer L,Miller DB,O'Callaghan JP

更新日期：2010-03-01 00:00:00

abstract：:The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as many of the effects, particularly during development, are unknown. The effects of these drugs upon homeostasis may be important since both are known to stimulate the hy...

journal_title：Neurotoxicology and teratology

authors： Graham DL,Herring NR,Schaefer TL,Vorhees CV,Williams MT

更新日期：2010-03-01 00:00:00

abstract：:Perfluorinated alkyls are widely-used agents that accumulate in ecosystems and organisms because of their slow rate of degradation. There is increasing concern that these agents may be developmental neurotoxicants and the present study was designed to develop an avian model for the neurobehavioral teratogenicity of pe...

journal_title：Neurotoxicology and teratology

authors： Pinkas A,Slotkin TA,Brick-Turin Y,Van der Zee EA,Yanai J

更新日期：2010-03-01 00:00:00

abstract：:The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. We established mechanistically-based complementary models for the study of cholinergic systems in...

journal_title：Neurotoxicology and teratology

authors： Yanai J,Brick-Turin Y,Dotan S,Langford R,Pinkas A,Slotkin TA

更新日期：2010-01-01 00:00:00

abstract：:Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...

journal_title：Neurotoxicology and teratology

authors： Fan CY,Cowden J,Simmons SO,Padilla S,Ramabhadran R

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. STUDY DESIGN:Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobac...

journal_title：Neurotoxicology and teratology

authors： Yolton K,Khoury J,Xu Y,Succop P,Lanphear B,Bernert JT,Lester B

更新日期：2009-11-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00

abstract：:This longitudinal study evaluated whether the level of intrauterine cocaine exposure (IUCE) or the interaction between IUCE and contextual variables was related during middle childhood to executive functioning, as assessed with the Stroop Color-Word and Rey Osterrieth Complex Figure tests. The Stroop Interference scor...

journal_title：Neurotoxicology and teratology

authors： Rose-Jacobs R,Waber D,Beeghly M,Cabral H,Appugleise D,Heeren T,Marani J,Frank DA

更新日期：2009-05-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Neurotoxicology and teratology

authors： Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

更新日期：2009-02-05 00:00:00

abstract：:The developmental neurotoxicity of organophosphates such as chlorpyrifos (CPF) involves multiple mechanisms that ultimately compromise the function of specific neurotransmitter systems, notably acetylcholine (ACh) and serotonin (5-hydroxytryptamine, 5HT). Studies in mammalian models incorporate both direct effects on ...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Ryde IT,Yanai J

更新日期：2008-09-01 00:00:00

abstract：:With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

更新日期：2008-07-01 00:00:00

abstract：:Toluene can be considered an ototoxic chemical compound in the rat. Outer hair cells are particularly sensitive to this aromatic organic solvent or to one of its metabolites. The objective of the present study was to evaluate the possible role played by cysteine S-conjugates in the ototoxic process in Long-Evans rats....

journal_title：Neurotoxicology and teratology

authors： Waniusiow D,Campo P,Cossec B,Cosnier F,Grossman S,Ferrari L

更新日期：2008-05-01 00:00:00

abstract：:The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

journal_title：Neurotoxicology and teratology

authors： Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

更新日期：2008-05-01 00:00:00

abstract：:Volatile organic solvent (inhalant) abuse continues to be a major health concern throughout the world. Of particular concern is the abuse of inhalants by adolescents because of its toxicity and link to illicit drug use. Toluene, which is found in many products such as glues and household cleaners, is among the most co...

journal_title：Neurotoxicology and teratology

authors： Bowen SE,Charlesworth JD,Tokarz ME,Wright MJ Jr,Wiley JL

更新日期：2007-11-01 00:00:00

abstract：:Risk assessment of developmental toxicants is almost exclusively based on single chemicals studied in animals under controlled experimental conditions, as to reduce stress. Although humans may be exposed simultaneously to numerous hazards, little is known about the interaction of prenatal chemical exposures with other...

journal_title：Neurotoxicology and teratology

authors： Hougaard KS,Hansen AM

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

journal_title：Neurotoxicology and teratology

authors： Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

更新日期：2007-05-01 00:00:00

abstract：:Pyrethroids are pesticides with high insecticidal activity and relatively low potency in mammals. The influence of dosing volume on the neurobehavioral syndrome following oral acute exposure to the Type-I pyrethroid insecticide bifenthrin in corn oil was evaluated in adult male Long Evans rats. We tested bifenthrin ef...

journal_title：Neurotoxicology and teratology

authors： Wolansky MJ,McDaniel KL,Moser VC,Crofton KM

更新日期：2007-05-01 00:00:00

abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...

journal_title：Neurotoxicology and teratology

authors： Yin HS,Tan HW

更新日期：2007-03-01 00:00:00

abstract：:Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that ove...

journal_title：Neurotoxicology and teratology

authors： Church MW,Jen KL,Stafferton T,Hotra JW,Adams BR

更新日期：2007-03-01 00:00:00

abstract：:Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world....

journal_title：Neurotoxicology and teratology

authors： Bowen SE,Mohammadi MH,Batis JC,Hannigan JH

更新日期：2007-03-01 00:00:00

abstract：:Numerous experiments have shown that the aromatic solvents can affect the auditory system in the rat, the cochlea being targeted first. Solvents differ in cochleotoxic potency: for example, styrene is more ototoxic than toluene or xylenes. The goal of this study was to determine the relative ototoxicity of the three i...

journal_title：Neurotoxicology and teratology

authors： Maguin K,Lataye R,Campo P,Cossec B,Burgart M,Waniusiow D

更新日期：2006-11-01 00:00:00

abstract：UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...

journal_title：Neurotoxicology and teratology

authors： Roldan-Tapia L,Nieto-Escamez FA,del Aguila EM,Laynez F,Parron T,Sanchez-Santed F

更新日期：2006-11-01 00:00:00

abstract：:Pregnant rats received daily injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs, on days 13-20 of gestation. Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in ...

journal_title：Neurotoxicology and teratology

authors： Bhat R,Chari G,Rao R,Wirtshafter D

更新日期：2006-09-01 00:00:00

abstract：:This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

journal_title：Neurotoxicology and teratology

authors： Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

更新日期：2006-05-01 00:00:00